Ethanol Stabilizes the Open State of Single 5-Hydroxytryptamine3A(QDA) Receptors

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Ethanol stabilizes the open state of single 5-hydroxytryptamine(3A)(QDA) receptors.

Ethanol enhancement of 5-hydroxytryptamine (5-HT)(3A) receptor-mediated responses may have important consequences in the intoxicating and addictive properties of ethanol. Although the exact mechanism is unknown, ethanol-mediated enhancement of 5-HT(3) receptor current has been proposed to occur due to stabilization of the open-channel state. It has not been possible to directly measure the open...

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ژورنال

عنوان ژورنال: Journal of Pharmacology and Experimental Therapeutics

سال: 2010

ISSN: 0022-3565,1521-0103

DOI: 10.1124/jpet.109.164863